The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 16, 1999
Filed:
Feb. 24, 1995
Applicant:
Inventors:
James M Wilson, Gladwyne, PA (US);
Yiping Yang, Philadelphia, PA (US);
Giorgio Trinchieri, Wynnewood, PA (US);
Assignees:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
The Wistar Institute of Anatomy & Biology, Philadelphia, PA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; A61K / ; A61K / ;
U.S. Cl.
CPC ...
514885 ; 424 852 ; 424 855 ; 4241541 ; 4242331 ; 424 932 ; 424 936 ; 514 49 ; 514 50 ; 514 44 ; 4353201 ; 435 691 ;
Abstract
A method of reducing an immune response to a recombinant adenovirus which involves co-administration of the recombinant adenovirus and a selected immune modulator. The immune modulator functions by inhibiting the formation of neutralizing antibodies and/or reducing CTL killing of the virally infected cells. The method additionally encompasses the step of re-administering the recombinant adenovirus.