The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 02, 1999
Filed:
May. 22, 1995
Applicant:
Inventors:
Sanford D Markowitz, Shaker Heights, OH (US);
Michael G Brattain, Maumee, OH (US);
James K Willson, Shaker Heights, OH (US);
Assignees:
Case Western Reserve University, Cleveland, OH (US);
Medical College of Ohio, Toledo, OH (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N / ; G01N / ;
U.S. Cl.
CPC ...
435-6 ; 435-71 ; 435-72 ; 435-721 ; 435-723 ; 436503 ; 436811 ;
Abstract
This invention is based on the discovery that the type II TGF-.beta. receptor (RII) is a cancer suppressor gene which is genetically inactivated (mutated) in approximately 25% of colon cancers, including nearly all colon cancers of the class identified as mutator/microsatellite instability/RER. Methods are provided for detecting inactivation of RII for use in cancer diagnosis or prognosis.