The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 19, 1999
Filed:
Oct. 31, 1996
Emad S Alnemri, Ambler, PA (US);
Teresa Fernandes-Alnemri, Ambler, PA (US);
Gerald Litwack, Wynnewood, PA (US);
Thomas Jefferson University, Philadelphia, PA (US);
Abstract
A substantially pure protein, immunophilin FKBP46, is disclosed. An isolated nucleic acid molecule that comprises a nucleic acid sequence that encodes immunophillin FKBP46, is disclosed. An isolated nucleic acid molecule consisting of a nucleic acid sequence that encodes immunophillin FKBP46, or a fragment thereof having at least 10 nucleotides is disclosed. Recombinant expression vector comprising a nucleic acid sequence that encodes immunophillin FKBP46 and host cells comprising the recombinant expression vector are disclosed. Oligonucleotide molecule comprising a nucleotide sequence complimentary to a nucleic acid sequence that encodes immunophillin FKBP46 of at least 5 nucleotides are disclosed. Antibodies that binds to an epitope on FKBP46 are disclosed. Methods of identifying immunosuppressive drugs comprising the steps of contacting FKBP46 or a homologous protein derived from yeast with a test compound and determining whether the protein binds to the test compound are disclosed.