The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 12, 1999
Filed:
Jun. 26, 1996
Gregory A Demopulos, Mercer Island, WA (US);
Pamela A Pierce, Tiburon, CA (US);
Jeffrey M Herz, Mill Creek, WA (US);
Omeros Medical Systems, Inc., Seattle, WA (US);
Abstract
A method and solution for perioperatively inhibiting a variety of pain, inflammation and smooth muscle spasm processes resulting from urologic procedures. The solution preferably includes multiple pain and inflammation inhibitory agents and spasm inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is introduced luminally to continuously irrigate a urologic structure during a urologic procedure for preemptive inhibition of pain and inflammation and smooth muscle spasm while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain, inflammation, and spasm includes a serotonin.sub.2 antagonist, a histamine.sub.1 antagonist, a cyclooxygenase inhibitor, a neurokinin.sub.2 antagonist, a purine.sub.2X antagonist, an ATP-sensitive K.sup.+ channel antagonist, a Ca.sup.2+ channel antagonist, one or more nitric oxide donors, a bradykinin.sub.1 antagonist and a bradykinin.sub.2 antagonist.