The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 05, 1999

Filed:

May. 02, 1997
Applicant:
Inventors:

Stephen E Webber, San Diego, CA (US);

Peter S Dragovich, Encinitas, CA (US);

Thomas J Prins, Cardiff, CA (US);

Siegfried H Reich, San Diego, CA (US);

Thomas L Little, Jr, Redmond, WA (US);

Ethel S Littlefield, San Diego, CA (US);

Joseph T Marakovits, Encinitas, CA (US);

Robert E Babine, Carlsbad, CA (US);

Ted M Bleckman, La Jolla, CA (US);

Assignee:

Agouron Pharmaceuticals, Inc., La Jolla, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D / ; C07D / ; C07C / ; C07C / ;
U.S. Cl.
CPC ...
549478 ; 549483 ; 549488 ; 560122 ; 560128 ; 560 27 ;
Abstract

Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of picornaviral 3C proteases. These compounds, as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses. Several novel methods and intermediates can be used to prepare the novel picornaviral 3C protease inhibitors of the present invention.


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