The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 29, 1998
Filed:
Dec. 29, 1994
Applicant:
Inventors:
David C Kaslow, Kensington, MD (US);
Philip J Barr, Oakland, CA (US);
Assignees:
The United States of America as represented by the Department of Health, , US;
Chiron Corporation, Emeryville, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C12N / ; C12N / ; C12P / ;
U.S. Cl.
CPC ...
4242681 ; 4241841 ; 4241851 ; 4242721 ; 530350 ; 435 691 ; 435 693 ; 435 699 ; 435 711 ; 435255 ;
Abstract
The present invention relates to transmission-blocking vaccines against malaria. Vaccines of the present invention contain a recombinant Pfs25 Plasmodium falciparum protein produced by yeast cells and to yeast cells producing the protein. Mice and monkeys inoculated with the yeast-expressed Pfs25 of the present invention have developed antibodies with transmission-blocking activity. The present invention also relates to methods of preventing or treating malarial infections using the vaccines of the present invention.