The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 22, 1998
Filed:
Apr. 10, 1995
Applicant:
Inventors:
Gordan Dougan, Beckenham, GB;
Steven Neville Chatfield, Beckenham, GB;
Christopher Francis Higgins, Oxford, GB;
Charles James Dorman, Dundee, GB;
Assignees:
Glaxo Wellcome Inc., Research Triangle Park, NC (US);
The Royal Society, London, GB;
The Lister Institute of Preventive Medicine, Middlesex, GB;
The University Court of The University of Dundee, Dundee, GB;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; A61K / ;
U.S. Cl.
CPC ...
424 932 ; 424 931 ; 424 934 ; 4241841 ; 4242581 ; 4242001 ; 4242011 ; 4242031 ;
Abstract
The present invention discloses a novel approach to attenuating bacteria and for their use as live vaccines. The vaccines can be used in human and animal medicine. In particular, there is disclosed a method of attenuating a bacteria by mutating a gene concerned with the regulation of one or more genes concerned with expression of outer membrane proteins, particularly porin proteins.