The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 15, 1998
Filed:
May. 12, 1997
Kozo Akasaka, Ibaraki, JP;
Masahiro Yonaga, Ibaraki, JP;
Akiharu Kajiwara, London, GB;
Kunizo Higurashi, Chiba, JP;
Kohshi Ueno, Ibaraki, JP;
Satoshi Nagato, London, GB;
Makoto Komatsu, Ibaraki, JP;
Noritaka Kitazawa, Ibaraki, JP;
Masataka Ueno, Ibaraki, JP;
Yoshiharu Yamanishi, Ibaraki, JP;
Yoshimasa Machida, London, GB;
Yuki Komatsu, Ibaraki, JP;
Naoyuki Shimomura, Ibaraki, JP;
Norio Minami, Ibaraki, JP;
Toshikazu Shimizu, Ibaraki, JP;
Atsushi Nagaoka, Ibaraki, JP;
Eisai Co., Ltd., Tokyo, JP;
Abstract
A biphenyl derivative represented by the following formula (I) or a pharmacologically acceptable salt thereof: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are defined in the specification, is clinically useful for treating and ameliorating mental disorders such as cerebrovascular disorder, aggressive behavior due to senile dementia, mental excitation, poriomania, delirium, hallucination, hyperkinesia, schizophrenia, emotional disturbance, depression, neurosis, psychophysiologic disorder and anxiety neurosis. The compounds exhibit dopamine 2 receptor antagonism and/or serotonin 2 receptor antagonism.