The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 15, 1998
Filed:
Jun. 07, 1995
H Michael Kolb, Cincinnati, OH (US);
Joseph P Burkhart, West Chester, OH (US);
Michel J Jung, Pfaffenhoffen, FR;
Fritz E Gerhart, deceased, late of Kehl Leutesheim, DE;
Eugene L Giroux, Cincinnati, OH (US);
Bernhard Neises, Offenburg-Griesheim, DE;
Daniel G Schirlin, Lampertheim, FR;
Merrell Pharmaceuticals Inc., Cincinnati, OH (US);
Abstract
This invention relates to analogs of peptidase substrates in which the amide group containing the scissile amide bond of the substrate peptide has been replaced by an activated electrophilic ketone moiety. These analogs of the peptidase substrates provide specific enzyme inhibitors for a variety of proteases, the inhibition of which will have useful physiological consequences in a variety of disease states.