The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 15, 1998
Filed:
Aug. 28, 1995
Applicant:
Inventors:
Rolf Gericke, Seeheim-Jugenheim, DE;
Dieter Dorsch, Ober-Ramstadt, DE;
Manfred Baumgarth, Ober-Ramstadt, DE;
Klaus-Otto Minck, Ober-Ramstadt, DE;
Norbert Beier, Reinheim, DE;
Assignee:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ;
U.S. Cl.
CPC ...
514618 ; 514522 ; 514599 ; 514616 ; 514821 ; 514824 ; 514866 ; 514921 ; 558412 ; 558413 ; 567 74 ; 567154 ; 567162 ;
Abstract
Ortho-substituted benzoic acid derivatives of the formula I ##STR1## in which R.sup.1, R.sup.2 and R.sup.3 have the given meanings, and Q is guanidyl, and also their physiologically harmless salts, exhibit antiarrhythmic properties and act as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter. In addition, the compounds of the formula I, in which R.sup.1 to R.sup.3 and also Q have the given meanings, are suitable for use as valuable intermediates for the preparation of medicaments, in particular of inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter.