The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 08, 1998

Filed:

Jul. 01, 1997
Applicant:
Inventors:

Shinji Yokoyama, Saitama-ken, JP;

Noriyoshi Sueda, Saitama-ken, JP;

Hiroaki Yamada, Saitama-ken, JP;

Ryotaro Kojima, Saitama-ken, JP;

Koichi Katsuyama, Tokyo, JP;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; C07C / ; C07D / ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
540529 ; 514212 ; 514352 ; 514357 ; 514376 ; 514398 ; 514423 ; 514440 ; 514466 ; 514471 ; 514616 ; 546312 ; 546337 ; 548229 ; 5483185 ; 548540 ; 549 77 ; 549439 ; 549496 ; 564152 ; 564155 ;
Abstract

Imide compounds having a propioloyl group or pharmaceutically acceptable salts thereof which exhibit potent activities to inhibit the production of Interleukin 1-.beta. and also the production of Tumor Necrosis Factor .alpha.. These imide compounds are useful as a prophylactic or therapeutic agent for inhibiting the production of Interleukin 1-.beta. and the production of Tumor Necrosis Factor .alpha., typically for such diseases as chronic rheumatism, sepsis, ulcerative colitis, Crohn's disease and many other related diseases in which Interleukin 1-.beta. and/or Tumor Necrosis Factor .alpha. would participate.


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