The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 01, 1998
Filed:
Nov. 06, 1996
Applicant:
Inventor:
Urs Albert Meyer, Oberwil, CH;
Assignee:
Roche Molecular Systems, Inc., Branchburg, NJ (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07H / ; C12P / ; C12Q / ;
U.S. Cl.
CPC ...
536 2433 ; 435-6 ; 435 911 ; 435 912 ; 536 231 ; 536 235 ; 536 243 ; 536 2431 ; 935 76 ; 935 77 ; 935 78 ;
Abstract
A method for the detection of poor metabolizers of drugs using PCR technology is described comprising a) optionally amplifying a gene coding for an enzyme known to be responsible for the metabolization of drugs, thereby separating it from possible closely related pseudogens, b) amplifying different allelic forms of the gene of step a) and c) detecting the product of step b). Primers for amplification of the genes responsible for the debrisoquine or acetylation phenotype are also disclosed.