The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 01, 1998
Filed:
Dec. 20, 1995
Guy W Bemis, Arlington, MA (US);
John P Duffy, Brighton, MA (US);
Wolf Herman Fridman, Paris, FR;
Julian M Golec, Ashbury, GB;
David J Livingston, Newtonville, MA (US);
Michael D Mullican, Needham, MA (US);
Mark A Murcko, Holliston, MA (US);
Robert E Zelle, Stow, MA (US);
Vertex Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
The present invention relates to novel classes of compounds which are inhibitors of interleukin-1.beta. converting enzyme. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting ICE activity and consequently, may be advantageously used as agents against interleukin-1 and apoptosis-mediated diseases, including inflammatory diseases, autoimmune diseases, proliferative, infectious, and degenerative diseases. This invention also relates to methods for inhibiting ICE activity and methods for treating interleukin-1 mediated diseases using the compounds and compositions of this invention.