The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 01, 1998
Filed:
Dec. 30, 1994
Applicant:
Inventors:
Lan Bo Chen, Lexington, MA (US);
Shideng Bao, Cambridge, MA (US);
Assignee:
Other;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N / ; C12N / ; C27H / ;
U.S. Cl.
CPC ...
4351723 ; 435-6 ; 435183 ; 4353201 ; 435325 ; 536 231 ; 536 232 ; 536 235 ;
Abstract
We have now discovered that eukaryotes, including mammals, have a gene that encodes a multifunctional protein having helicase activity, DNA repair activity, p53 sequestering activity and oncogenetic transformation potential. Enhanced transcripts and expression of this gene in non-testicular cells have a high correlation to disease state in a number of cancers, such as colorectal carcinomas, hereditary cancers resulting from defects in DNA repair pathways, breast cancers, etc. Accordingly, discovering enhanced levels of transcript or gene product in non-testicular tissues can be diagnostic of a predisposition to cancer, and prognostic for a particular cancer.