The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 01, 1998

Filed:

Dec. 11, 1996
Applicant:
Inventors:

Nadine Michele Gan, Newtown Centre, MA (US);

Gary Thomas Overmeyer, Tewksbury, MA (US);

Douglas Roger Shaw, Cambridge, MA (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; C07F / ; C07K / ;
U.S. Cl.
CPC ...
424-141 ; 424-145 ; 424-149 ; 424-165 ; 424-169 ; 424-173 ; 424-153 ; 5303913 ; 534 10 ;
Abstract

A stabilized composition comprising an organic compound labeled with a .beta.-emitting radionuclide and a stabilizing effective amount of a non-radiolabeled stabilizing compound selected from the group consisting of (i) heteroaryls having at least one nitrogen atom, said heteroaryl being substituted with at least one sulfur-containing moiety selected from the group consisting of thiol and thiocarbonyl provided that the nitrogen atoms are not adjacent to one another; (ii) aryls being substituted with at least one nitrogen-containing moiety selected from the group consisting of amino and isothiocyanate and with at least one sulfur-containing moiety selected from the group consisting of sulfonamide, sulfonate, and thiol; and (iii) alkylamines having at least one to four carbon atoms, said alkylamine being substituted with at least one sulfur-containing moiety selected from the group consisting of thioacid and thiocarbonyl provided that when the sulfur-containing moiety is a thioacid then the aminoalkyl contains only one nitrogen atom.


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