The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 24, 1998
Filed:
Oct. 23, 1995
Applicant:
Inventor:
Ing-Jun Chen, Kaohsiung, TW;
Assignee:
Tong-Ho Lin, Taipei, TW;
Primary Examiner:
Int. Cl.
CPC ...
C07D / ;
U.S. Cl.
CPC ...
5442305 ; 544 90 ;
Abstract
A series of 4-O & 5-aminomethylation of synthetic capsaicin derivatives selectively reveal antagonist activity on capsaicin-sensitive sensory neurons, and inhibit its innervating atrium, airway, and ileum smooth muscles in vitro. The compound of this invention has the following formula ##STR1## wherein R is a member selected from the group consisting of ##STR2## wherein R.sub.1 is a member selected from the group consisting of C.sub.1-12 alkyl, C.sub.1-12 alkenyl, C.sub.1-12 alkylene, and C.sub.1-12 alkenylene, and wherein R.sub.2 is a member selected from the group consisting of H, C.sub.1-3 alkylene-NR.sub.1 R.sub.1, and C.sub.1-6 alkenylene-NR.sub.1 R.sub.1.