The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 24, 1998
Filed:
Mar. 01, 1995
Applicant:
Inventors:
Laura C Simmons, Burlingame, CA (US);
Daniel G Yansura, Pacifica, CA (US);
Assignee:
Genetech, Inc., S. San Francisco, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12P / ; C12N / ; C07H / ; C12Q / ;
U.S. Cl.
CPC ...
435 691 ; 435-6 ; 4351723 ; 536 237 ; 536 241 ;
Abstract
The instant invention discloses the unexpected result that mutant signal sequences with reduced translational strength provided essentially complete processing and high levels of expression of a polypeptide of interest as compared to wild type signal sequences, and that many mammalian polypeptides require a narrow range of translation levels to achieve maximum secretion. A set of signal sequence vectors provides a range of translational strengths for optimizing expression of a polypeptide of interest.