The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 17, 1998
Filed:
Jun. 07, 1995
Applicant:
Inventors:
Hendrik Timmerman, Voorschoten, NL;
Henderikus Van Der Goot, Hoofddorp, NL;
Assignee:
Seed Capital Investment (SCI) B.V., GA Utrecht, NL;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; C07D / ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
514341 ; 514398 ; 514400 ; 546278 ; 5483265 ; 5483291 ; 5483361 ;
Abstract
##STR1## The invention relates to imidazole-derivatives of general formula (a). The invention in particular relates to derivatives having agonistic or antagonistic activity on the histamine H.sub.3 -receptor. The novel imidazole-derivatives are isothio urea-, guanidine- and amidine-derivatives. The invention further relates to pharmaceutical compositions comprising the novel imidazole-derivatives as well as to methods for preparing the derivatives and for preparing pharmaceutical compositions having antagonistic and agonistic activity on the histamine 3 receptor.