The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 17, 1998
Filed:
Oct. 15, 1996
Applicant:
Inventors:
Volker Breu, Schliengen, DE;
Kaspar Burri, Binningen, CH;
Jean-Marie Cassal, Mulhouse, FR;
Martine Clozel, St. Louis, FR;
Georges Hirth, Huningue, FR;
Bernd-Michael Loffler, Oberrimsingen, DE;
Marcel Muller, Frenkendorf, CH;
Werner Neidhart, Hagenthal le Bas, FR;
Henri Ramuz, Birsfelden, CH;
Assignee:
Hoffmann-La Roche Inc., Nutley, NJ (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D / ; C07D / ; C07D / ; A61K / ;
U.S. Cl.
CPC ...
514274 ; 5142278 ; 5142282 ; 5142285 ; 5142358 ; 5142365 ; 5142322 ; 5142325 ; 5142348 ; 5142345 ; 514252 ; 514249 ; 514259 ; 514262 ; 514261 ; 514269 ; 544319 ; 544238 ; 544295 ; 544296 ; 544122 ; 544123 ; 544 82 ; 544 586 ; 544265 ; 544276 ; 544277 ; 544284 ;
Abstract
Compounds of the formula ##STR1## wherein the variables are hereinbelow defined. The compounds of formula I are inhibitors for endothelin receptors. They can be used for the treatment of disorders which are associated with endothelin activities, especially circulatory disorders such as hypertension, ischaemia, vasospasms and angina pectoris.