The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 17, 1998
Filed:
Feb. 22, 1995
Karl-Dieter Entian, Oberursel, DE;
Friedrich Gotz, Tubingen, DE;
Norbert Schnell, Pasadena, CA (US);
Johannes Augustin, Tubingen, DE;
Germar Engelke, Frankfurt am Main, DE;
Ralf Rosenstein, Reutlingen, DE;
Cortina Kaletta, Munich, DE;
Cora Klein, Offenbach, DE;
Bernd Wieland, Rottenburg, DE;
Thomas Kupke, Tubingen, DE;
Gunther Jung, Tubingen, DE;
Roland Kellner, Heppenheim, DE;
Dr. Karl Tomae GmbH, Biberach an der Riss, DE;
Abstract
A bacterial host is described which is transformed by a plasmid coding for a polypeptide precursor wherein the host comprises a multi-enzyme complex capable of reacting with the expressed polypeptide precursor to produce a polypeptide comprising at least one dehydroamino acid and/or at least one lanthionine bridge. A process for producing a polypeptide comprising at least one dehydroamino acid and/or at least one lanthionine bridge, such as gallidermin, is also described. A plasmid capable of transforming a bacterial host is additionally described. Also disclosed are recombinant DNA molecules which specify Epi B, Epi C, Epi D, Epi P and Epi Q, enzymes which are involved in the biosynthesis of lantibiotic epidermin.