The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 17, 1998
Filed:
Aug. 26, 1997
Cynthia K Lee, Needham, MA (US);
Thomas P Monath, Harvard, MA (US);
Samuel K Ackerman, Weston, MA (US);
William D Thomas, Winchester, MA (US);
Gopalan Soman, Belmont, MA (US);
Harold Kleanthous, Allston, MA (US);
Richard A Weltzin, Lunenburg, MA (US);
Jacques Pappo, Newton, MA (US);
Thomas Ermak, Brookline, MA (US);
Farshad Guirakhoo, Melrose, MA (US);
Hitesh Bhagat, Framingham, MA (US);
Ilene Sussman, Newton, MA (US);
OraVax-Merieux Co., Cambridge, MA (US);
Abstract
Methods and compositions are provided for prophylactic and antibacterial therapy for Helicobacter, particularly for Helicobacter pylori, infection of humans. The immunogenic composition of the invention is composed of a plurality of multimeric complexes, each complex being composed of recombinant, enzymatically inactive Helicobacter pylori urease. Each multimeric complex is composed of six Urease A subunits and six Urease B subunits. Alternatively, the composition is composed of a mixture of multimeric complexes, wherein each multimeric complex in the mixture is composed of six Urease A subunits and six Urease B subunits or four Urease A subunits and four Urease B subunits.