The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 10, 1998
Filed:
May. 01, 1996
Elaine Tuomanen, New York, NY (US);
H Robert Masure, New York, NY (US);
Theresa M Wizemann, New York, NY (US);
The Rockefeller University, New York, NY (US);
Abstract
The present invention relates to the identification of a bacterial adhesion associated protein, and the gene encoding such protein. More particularly, the invention relates to a pneumococcal peptide methionine sulfoxide reductase involved in bacterial adherence. The invention also relates to identification and development of agents to provide protection from bacterial infection based on this protein. The invention provides nucleic acids encoding the peptide methionine sulfoxide reductase, as well as methods for identifying antagonists of the methionine sulfoxide reductase. The present invention further demonstrates that peptide methionine sulfoxide reductase is an adhesion-associated protein in various Gram-negative and Gram-positive bacteria and accordingly provides for interference with the peptide methionine sulfoxide reductase to inhibit bacterial adherence to host tissues.