The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 10, 1998
Filed:
Feb. 13, 1997
Joseph W Becker, Bridgewater, NJ (US);
Donald W Nicholson, Montreal, CA;
Jennifer Rotonda, Nutley, NJ (US);
Nancy A Thornberry, Westfield, NJ (US);
Kimberly M Fazil, Markham, CA;
Michel Gallant, Montreal, CA;
Yves Gareau, Notre-Dame-De-Lile-Perrot, CA;
Marc Labelle, Ville Ile Perrot, CA;
Erin P Peterson, Westfield, NJ (US);
Dita M Rasper, Pierrefonds, CA;
Rejean Ruel, Pointe Claire, CA;
John P Vaillancourt, Pierrefonds, CA;
Merck & Co., Inc., Rahway, NJ (US);
Merck Frosst Canada, Inc., Kirkland, CA;
Abstract
The apopain:Ac-DEVD-CHO complex has been crystallized and its structure determined by x-ray crystallography. Based upon this crystal structure of the complex, a method for identifying inhibitors of apopain is presented which comprises designing putative inhibitors having specific contacts with apopain, making the putative inhibitors, and testing the putative inhibitors for their ability to inhibit apopain.