The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 03, 1998
Filed:
Apr. 11, 1996
David L Arendsen, Libertyville, IL (US);
William R Baker, Bellevue, WA (US);
Stephen A Fakhoury, Mundelein, IL (US);
Anthony K Fung, Gurnee, IL (US);
David S Garvey, Dover, MA (US);
William J McClellan, Waukegan, IL (US);
Stephen J O'Connor, Wilmette, IL (US);
Rajnandan N Prasad, Vernon Hills, IL (US);
Todd W Rockway, Grayslake, IL (US);
Saul H Rosenberg, Grayslake, IL (US);
Herman H Stein, Highland Park, IL (US);
Wang Shen, Skokie, IL (US);
David M Stout, Mettawa, IL (US);
Gerard M Sullivan, Round Lake Beach, IL (US);
David J Augeri, Kenosha, WI (US);
Abbott Laboratories, Abbott Park, IL (US);
Abstract
The present invention provides a compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof, which are useful for inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras or inhibiting de novo squalene production resulting in the inhibition of cholesterol biosynthesis, processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and to methods of using such compounds.