The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 03, 1998

Filed:

Feb. 08, 1996
Applicant:
Inventors:

Irena Y Bronstein, Newton, MA (US);

Brooks Edwards, Cambridge, MA (US);

Rouh-Rong Juo, Alston, MA (US);

Assignee:

Tropix, Inc., Bedford, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D / ;
U.S. Cl.
CPC ...
549332 ; 435-6 ; 435-71 ; 435 21 ; 435810 ; 436172 ; 436800 ; 436808 ; 549200 ; 549201 ; 549218 ; 549330 ; 549510 ; 549511 ; 560-1 ; 560 18 ; 560 19 ; 560 22 ; 560 64 ; 560 66 ; 568-8 ; 568300 ; 568579 ; 568580 ; 568583 ; 568628 ; 568659 ; 568662 ; 568663 ; 568700 ; 568701 ; 568704 ; 568715 ; 570101 ; 570102 ; 570123 ; 570127 ; 570140 ; 570181 ; 570182 ; 570183 ; 935 77 ; 935 78 ;
Abstract

Enzymatically cleavable chemiluminescent 1,2-dioxetane compounds capable of producing light energy when decomposed, substantially stable at room temperature before a bond by which an enzymatically cleavable labile substituent thereof is intentionally cleaved, are disclosed. These compounds can be represented by the formula: ##STR1## wherein: X and X.sup.1 each represent, individually, hydrogen, a hydroxyl group, a halo substituent, an unsubstituted lower alkyl group, a hydroxy (lower) alkyl group, a halo (lower) alkyl group, a phenyl group, a halophenyl group, an alkoxyphenyl group, a hydroxyalkoxy group, a cyano group or an amide group, with at least one of X and X.sup.1 being other than hydrogen; and


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