The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 20, 1998
Filed:
Aug. 30, 1996
Chaim Manor, Shoreview, MN (US);
Jia Wei, Stillwater, MN (US);
Gordon D MacFarlane, Minneapolis, MN (US);
INCSTAR Corporation, Stillwater, MN (US);
Abstract
Galactosylhydroxylysine is a terminal degradation product of the bone matrix which thus serves as biochemical marker of bone resorption. A method of synthesizing galactosylhydroxylysine is provided. Antibodies against this synthetically prepared galactosylhydroxylysine conjugated to protein carriers were raised to establish methods to measure galactosylhydroxylysine in biological fluids. The antibodies of the invention recognize native galactosylhydroxylysine and are, for example, useful in the measurement of galactosylhydroxylysine as a biochemical marker of bone resorption in biological fluids. Testing of human serum or adolescent urine resulted in dose-dependent increases in signal intensity using the method of the invention.