The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 20, 1998
Filed:
Sep. 02, 1994
Applicant:
Inventors:
Gad Lavie, Rehovot, IL;
Alfred M Prince, Pound Ridge, NY (US);
Assignees:
New York University, New York, NY (US);
New York Blood Center, New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C09B / ; C12N / ;
U.S. Cl.
CPC ...
514 44 ; 4351721 ; 4351723 ; 4352401 ; 530324 ; 536 231 ; 552282 ; 935 52 ;
Abstract
The invention provides improved methods for delivery of nucleic acids to cells, which comprise forming ternary complexes between a hydrophobic, membrane-binding anion such as hypericin; a polycation such as polylysine; and a nucleic acid such as DNA; and contacting cells with the tenary complexes. Also provided are pharmaceutical formulations comprising these ternary complexes and a pharmaceutically acceptable carrier or diluent. The methods and compositions find use in mediating DNA uptake into cells, including gene therapy applications.