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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 5824501 B1

PDFFull Text
Date of Patent:
Oct. 20, 1998

Filed:

Nov. 15, 1995

Nucleic acids of the bloom's syndrome gene

Applicant:
Inventors:

Nathan A Ellis, New York, NY (US);

James German, New York, NY (US);

Joanna Groden, Cincinnati, OH (US);

Assignees:

New York Blood Center, New York, NY (US);

University of Cincinnati, Cincinnati, OH (US);

Attorney:

Amster, Rothstein & Ebenstein

Primary Examiner:

Jasemine C Chambers

Assistant Examiner:

Scott D Priebe

Int. Cl.
CPC ...
C12N / ; C12N / ; C12N / ; C07H / ;
U.S. Cl.
CPC ...
435 691 ; 4352523 ; 43525411 ; 435325 ; 4353201 ; 4351723 ; 536 231 ; 536 232 ; 536 235 ;
Abstract

The present invention provides a method for diagnosing BS as well as determining whether a subject is a carrier of a mutated BLM gene. The present invention also provides one or more single-stranded nucleic acid probes and antibodies which may be formulated in kits, and used for diagnosing BS or determining whether a subject is a carrier of a mutated BLM gene. In addition, the present invention provides a method for treating or preventing the onset of BS in a subject in need of such treatment or prevention, as well as vectors and stem cells useful for such treatment or prevention. The present invention also provides a purified and isolated nucleic acid encoding an enzymatically active BLM protein, a vector comprising this nucleic acid, a cell stably transformed with this vector, as well as a method for producing recombinant, enzymatically active BLM protein. A purified, enzymatically active BLM protein is also provided by the present invention. Finally, the present invention provides a vector, an embryonic stem cell, and a non-human, transgenic animal, each of which comprises a mutated BLM gene, as well as a method for producing the non-human, transgenic animal.

Find Patent Forward Citations

Ellis, Nathan. (1998). Nucleic acids of the bloom's syndrome gene (U.S. Patent No. 5824501). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/5824501

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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