The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 13, 1998
Filed:
Dec. 04, 1996
Yukihiro Fusauchi, Maebashi, JP;
Hiroshi Yoshikawa, Fujioka, JP;
Nippon Kayaku Kabushiki Kaisha, Tokyo, JP;
Abstract
A protected 4'-demethyl-4-epipodophyllotoxin is reacted with a protected glucose derivative in a non-halogen type organic solvent in a 0.1-7-fold parts by volume based on 1 part by weight of the protected 4'-demethyl-4-epipodophyllotoxin to give an etoposide derivative of formula (3) which is protected at its functional groups: ##STR1## wherein each of R.sub.1 and R.sub.2 each is a protective group for hydroxy, if necessary, followed by removal of these protective groups. By use of the non-halogen type organic solvent in lieu of any harmful halogen type solvent, formation of undesirable by-products can be minimized so that the etoposides can be obtained in a high yield and high purity.