The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 13, 1998
Filed:
Oct. 25, 1996
Kwang-Hoe Chung, Kyonggi-Do, KR;
You-Seok Koh, Seoul, KR;
Jae-Hoon Hwang, Seoul, KR;
Doo-Sik Kim, Seoul, KR;
Yung-Dae Yun, Seoul, KR;
Hong-Mo Moon, Kyonggi-Do, KR;
Mogam Biotechnology Research Institute, Kyonggi-Do, KR;
Abstract
The present invention relates to a novel cDNA of direct-acting fibrinolytic serine protease ('Salmonase') which is prepared from a Korean viper, Salmosa(Agkistrodon halys brevicaudus), and a direct-acting fibrinolytic serine protease deduced therefrom. The cDNA of direct-acting fibrinolytic serine protease contains 699 nucleotides coding for 233 amino acids, and the Salmonase translated therefrom consists of two subunits of 77 and 156 amino acids, respectively. Salmonase cDNA of the invention may be expressed in the proper systems established in the recombinant E. coli, yeast, baculovirus/insect cells and other animal cells, and the recombinant Salmonase prepared therefrom can be practically applied as an active ingredient of thrombolytic and hemostatic agents.