The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 06, 1998
Filed:
Mar. 14, 1995
Mark A Findeis, Boston, MA (US);
Howard Benjamin, Lexington, MA (US);
Marc B Garnick, Brookline, MA (US);
Malcolm L Gefter, Lincoln, MA (US);
Arvind Hundal, Brighton, MA (US);
Laura Kasman, Athens, GA (US);
Gary Musso, Hopkinton, MA (US);
Ethan R Signer, Cambridge, MA (US);
James Wakefield, Brookline, MA (US);
Michael J Reed, Oak Ridge, TN (US);
Praecis Pharmaceuticals Incorporated, Cambridge, MA (US);
Abstract
Compounds that act to modulate the aggregation of natural .beta. amyloid peptides (.beta.-AP) are disclosed. The .beta. amyloid modulators of the invention can promote .beta.-AP aggregation or, more preferably, can inhibit natural .beta.-AP aggregation. Furthermore, the modulators are capable of altering natural .beta.-AP aggregation when the natural .beta.-APs are in a molar excess amount relative to the modulators. Preferred .beta. amyloid modulators comprise amino-terminally biotinylated .beta. amyloid peptide compounds. Pharmaceutical compositions comprising the compounds of the invention, and methods of altering natural .beta.-AP aggregation using the compounds of the invention, are also disclosed.