The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 29, 1998
Filed:
Apr. 08, 1994
Applicant:
Inventor:
Clarence Frank Bennett, Carlsbad, CA (US);
Assignee:
Isis Pharmacuticals, Inc., Carlsbad, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K / ;
U.S. Cl.
CPC ...
514 44 ; 536 231 ;
Abstract
Certain oligonucleotides capable of inhibiting the production of p120, a cell proliferation-associated nucleolar protein, are provided. Oligonucleotides designed to be hybridizable with nucleic acids encoding nucleolar proteins are believed to be therapeutically useful. Certain of such oligonucleotides, hybridizable to MRNA encoding p120, were made and found to inhibit the synthesis of p120. The oligonucleotides of the invention are useful for the treatment of diseases characterized by hyperproliferation of cells. Methods of treatment and diagnosis of such diseases using these oligonucleotides are also provided.