The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 15, 1998
Filed:
Apr. 29, 1991
Applicant:
Inventors:
Timothy A McCaffrey, New York, NY (US);
Domenick J Falcone, Flushing, NY (US);
Assignee:
Cornell Research Foundation, Inc., Ithaca, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07K / ; C07K / ;
U.S. Cl.
CPC ...
530328 ; 530412 ; 536 21 ;
Abstract
The present invention relates to a method for purifying heparin into two subspecies of molecules, one which binds transforming growth factor-.beta. (TGF-.beta.), and another which does not. The method involves using a peptide, immobilized on a chromatography substrate, that is homologous to the heparin-binding region of TGF-.beta. and allowing the heparin to contact the immobilized peptide for a sufficient time to cause binding. The fraction of heparin which does not bind to the peptide retains its activity as an anticoagulant but is devoid of the ability to bind TGF-.beta..