The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 15, 1998
Filed:
Mar. 31, 1994
Applicant:
Inventor:
Scott F Rosebrough, Avon, NY (US);
Assignee:
University of Rochester, Rochester, NY (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; C07D / ;
U.S. Cl.
CPC ...
514387 ; 5483041 ; 424-149 ; 424-9362 ; 424-9363 ;
Abstract
The present invention provides biotinylated compounds useful for delivering a molecule to a target site, and methods of making biotinylated compounds. The biotinylated compounds are covalent conjugates of biotin and a diagnostic or therapeutic agent, and are stable to rapid degradation by biotinidase. The compounds of the invention are useful for delivering therapeutic or diagnostic agents to target-bound streptavidin or avidin conjugated cell-targeting agents, including monoclonal antibodies. The compound N-cysteinyl biotin is also provided.