The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 15, 1998

Filed:

Nov. 19, 1996
Applicant:
Inventors:

Nicholas James Bach, Indianapolis, IN (US);

Stephen Richard Baker, Surrey, GB;

Jeremy Gilmore, Surrey, GB;

Russell Andrew Lewthwaite, Cambridge, GB;

Alexander McKillop, Norwich, GB;

Jason Scott Sawyer, Indianapolis, IN (US);

George Richard Stephenson, Norwich, GB;

Michael William Urquhart, Kent, GB;

Assignees:

The University of East Anglia, Norwich, GB;

Eli Lilly and Company, Indianapolis, IN (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D / ; C07D / ; C07D / ; A61K / ;
U.S. Cl.
CPC ...
544284 ; 544353 ; 546174 ; 546175 ; 546176 ; 546177 ; 546273 ; 548159 ; 548548 ; 548181 ; 548217 ; 514249 ; 514259 ; 514314 ; 514339 ; 514365 ; 514367 ; 514374 ;
Abstract

A process for producing a compound of the formu5la ##STR1## comprising the step of reacting a compound of the formula ##STR2## with a compound of the formula ##STR3## to form a compound of the formula ##STR4## wherein R.sup.2a is selected from the groups recited above for R.sup.2, or R.sup.2a --X-- is a protected hydroxyl group, and Z is a group of formula --Y--R.sub.5 recited above, or a group that can be converted into a group of said formula --Y--R.sup.5. Intermediates of formula IV and composition containing substantially optically pure enantiomers of Formula (I) are included within the scope of the invention.


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