The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 15, 1998
Filed:
Jan. 31, 1996
Oliver Yoa-Pu Hu, Taipei, TW;
Other;
Abstract
An automated dissolution apparatus and method that simulates the physiological condition of gastrointestinal tract has been developed. The invention is capable of continuously adjusting the pH and enzyme content of dissolution medium with consideration of the transit time of a pharmaceutical dosage form. The apparatus includes a pH meter with recorder, a dissolution tester, a UV spectrophotometer, a dissolution data recorder with processor, a personal computer and a printer. The present invention can adjust the pH and enzyme content of a dissolution medium based on the literature information of human gastrointestinal conditions and transit times of various pharmaceutical dosage forms. Use of the present invention not only can change the pH and enzyme content of dissolution medium continueously, but also can differentiate the change of drug release and effects of pH and enzyme content on the drug release rate of pharmaceutical formulations.