The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 01, 1998
Filed:
May. 26, 1995
Jianshi Tao, Needham, MA (US);
Yan Qiu, Brookline, MA (US);
Fariba Houman, Belmont, MA (US);
Xiaoyu Shen, S. Boston, MA (US);
Paul R Schimmel, Cambridge, MA (US);
Cubist Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
Recombinant nucleic acids which encode aminoacyl-tRNA sythetases of helicobacter origin have been isolated. These nucleic acids can be used to make expression constructs and transformed host cells for the production of helicobacter aminoacyl-tRNA synthetases. They can also be used in the further isolation of nucleic acids related by DNA sequence similarities, which also encode helicobacter aminoacyl-tRNA synthetases, or portions thereof. A further embodiment of the invention is antisense nucleic acid which can hybridize to the nucleic acid which encodes the aminoacyl-tRNA synthetase of helicobacter. The invention also relates to isolated and/or recombinant helicobacter aminoacyl-tRNA synthetases. Antibodies which bind to these enzymes can be made and can be used in the purification and study of the enzymes. Also described are tester strains, which are cells engineered to rely on the function of the tRNA synthetase encoded by an introduced cloned gene, and which can be used to test the effectiveness of drug candidates in the inhibition of an essential aminoacyl-tRNA synthetase encoded by an introduced cloned helicobacter gene.