The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 18, 1998
Filed:
Jul. 09, 1997
Applicant:
Inventors:
Micsunica Platica, New York, NY (US);
Ovidiu Platica, New York, NY (US);
James F Holland, Scarsdale, NY (US);
Assignee:
Mount Sinai School of Medicine, New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N / ; C07K / ; C07H / ;
U.S. Cl.
CPC ...
435 691 ; 536 235 ; 536 2431 ; 4351723 ; 4353201 ; 435325 ; 4352523 ; 530530 ; 530399 ; 935-8 ; 935-9 ; 935 22 ;
Abstract
The present invention is directed to pituitary differentiation factor (PDF), a pituitary factor that is capable of differentiating cells including breast cancer and prostatic cancer cells. Isolated nucleic acids encoding PDF and related vectors and host cells are also provided. Restoration of differentiating ability to malignantly transformed cells provides a modality of cancer therapy. The isolated and purified PDF of the invention is accordingly useful in the treatment of breast and prostatic cancer.