The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 11, 1998
Filed:
May. 31, 1995
J R Petersen, Seabrook, TX (US);
Mohammad Amin Abubaker, Galveston, TX (US);
M G Bissell, Galveston, TX (US);
Board of Regents, The University of Texas System, Austin, TX (US);
Abstract
The present invention provides a method for direct detection concurrently with separation in capillary electrophoresis using a lanthanide cation selected from the group consisting of Tb(III), Eu(III), Dy(III), and Sm(III) to provide fluorescence for enhanced sensitivity. Analytes separated and concurrently detected using this method have an absorption spectrum from about 230 nm to 400 nm and include compounds having an .alpha.,.beta. unsaturated carbonyl group, an .alpha.-keto acid, an aromatic moiety, indole carboxylic acid, a diketone moiety, or an organic acid, for example, a salicylic acid, a carboxylic acid, or an amino acid. Advantages of this method include the lack of derivatization, either pre- or post-column, loss of analyte during derivatization is avoided, and fewer items are needed for a commercial capillary electrophoresis kit.