The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 04, 1998
Filed:
Jan. 31, 1994
Applicant:
Inventors:
Patrick J Casey, Durham, NC (US);
Fang Zhang, Durham, NC (US);
Ronald E Diehl, Line Lexington, PA (US);
Nancy E Kohl, Wyndmoor, PA (US);
Charles A Omer, Lansdale, PA (US);
Assignees:
Merck & Co., Inc., Rahway, NJ (US);
Duke University, Durham, NC (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N / ; C12N / ;
U.S. Cl.
CPC ...
536 232 ; 435193 ; 4353201 ;
Abstract
The present invention relates, in general, to a protein prenyltransferase and, in particular, to protein geranylgeranyltransferase (GGTase-I) and to a nucleic acid sequence encoding same. The invention also relates to methods of producing GGTase-I and geranylgeranyl modified polypeptides. The invention further relates to a method of screening compounds for the ability to alter GGTase-I activity.