The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 04, 1998
Filed:
Nov. 06, 1995
Harold Clinton Kluender, Trumbull, CT (US);
Guenter Hans Benz, Velbert, DE;
David Ross Brittelli, Branford, CT (US);
William Harrison Bullock, Hamden, CT (US);
Kerry Jeanne Combs, Wallingford, CT (US);
Brian Richard Dixon, Woodbridge, CT (US);
Stephan Schneider, Wuppertal, DE;
Jill Elizabeth Wood, Hamden, CT (US);
Michael Christopher VanZandt, New Haven, CT (US);
Donald John Wolanin, Orange, CT (US);
Scott M Wilhelm, Orange, CT (US);
Bayer Corporation, Pittsburgh, PA (US);
Abstract
Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The presently claimed compounds have the generalized formula ##STR1## in which each T represents a substituent group; x is 0, 1, or 2; D represents ##STR2## .delta. is 0 or 1; U' represents O, S, or N, with the proviso that when U' is N, then .delta.=0, and when U' is O or S, then .delta.=1; R.sup.14 is any of a variety of substituent groups; and G represents M, ##STR3## in which M represents --CO.sub.2 H, --CON(R.sup.11).sub.2, or --CO.sub.2 R.sup.12, R.sup.11 represents H or an alkyl group, R.sup.12 represents an alkyl group, and R.sup.13 represents any of the side chains of the 19 noncyclic naturally occurring amino acids; and pharmaceutically acceptable salts thereof.