The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 04, 1998
Filed:
Sep. 21, 1994
Applicant:
Inventors:
Alonzo H Ross, Shrewsbury, MA (US);
Wojciech Poluha, Shrewsbury, MA (US);
Mahesh B Lachyankar, Shrewsbury, MA (US);
Dorota K Poluha, Shrewsbury, MA (US);
Assignee:
Worcester Foundation for Experimental Biology, Shrewsbury, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q / ; A61K / ; C12N / ;
U.S. Cl.
CPC ...
435 29 ; 514 44 ; 4352402 ; 43524025 ; 435 691 ; 935 62 ;
Abstract
Disclosed is a method of reducing or inhibiting the tumorigenicity of a tumor cell in which a vector including a nucleotide sequence encoding a differentiation factor receptor, or a polypeptide portion thereof, is transferred to the tumor cell such that the nucleotide sequence is expressed. Tumorigenicity is monitored by cell growth and colony formation in a semi-soft medium, a reduction in proliferation being indicative of the reduction or inhibition of tumorigenicity of the treated tumor cell.