The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 21, 1998
Filed:
Jun. 07, 1995
Applicant:
Inventors:
Russell M Medford, Atlanta, GA (US);
Margaret K Offermann, Atlanta, GA (US);
R Wayne Alexander, Atlanta, GA (US);
Sampath Parthasarathy, Atlanta, GA (US);
Assignee:
Emory University, Atlanta, GA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; A61K / ; A61K / ;
U.S. Cl.
CPC ...
514423 ; 424-91 ; 424-92 ; 436 71 ; 436 86 ; 436129 ; 514 18 ; 5142262 ; 514477 ; 514478 ; 514479 ; 514484 ; 514485 ; 514487 ; 514488 ; 514489 ; 514506 ; 514513 ; 514517 ; 514518 ; 514553 ; 514561 ; 514824 ; 514825 ; 514826 ; 514861 ; 514863 ; 530331 ; 548431 ; 548531 ; 549 10 ; 558230 ; 558234 ; 558235 ; 558250 ; 562 26 ; 562 27 ; 564 76 ; 568 21 ; 568 25 ;
Abstract
Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of cardiovascular disease, including atherosclerosis, post-angioplasty restenosis, coronary artery diseases, and angina, as well as noncardiovascular inflammatory diseases that are mediated by VCAM-1.