The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 21, 1998

Filed:

Apr. 29, 1996
Applicant:
Inventors:

William R Baker, Bellevue, WA (US);

Saul H Rosenberg, Grayslake, IL (US);

Anthony K Fung, Gurnee, IL (US);

Todd W Rockway, Grayslake, IL (US);

Stephen A Fakhoury, Mundelein, IL (US);

David S Garvey, Dover, MA (US);

B Gregory Donner, Mundelein, IL (US);

Stephen J O'Connor, Wilmette, IL (US);

Rajnandan N Prasad, Vernon Hills, IL (US);

Wang Shen, Skokie, IL (US);

David M Stout, Mettawa, IL (US);

Gerard M Sullivan, Round Lake Beach, IL (US);

Assignee:

Abbott Laboratories, Abbott Park, IL (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; A61K / ; A61K / ;
U.S. Cl.
CPC ...
514381 ; 514 18 ; 514 19 ; 514533 ; 514542 ; 514557 ; 514559 ; 514561 ; 514562 ; 514563 ; 514572 ; 514613 ; 514616 ; 514617 ; 514619 ; 514621 ; 514729 ; 530330 ; 530331 ; 548251 ; 548253 ; 548254 ; 560 19 ; 560 37 ; 560 45 ; 560 48 ; 560 49 ; 560 76 ; 560123 ; 562405 ; 562426 ; 562433 ; 562442 ; 562443 ; 562452 ; 562465 ; 562480 ; 562488 ; 562489 ; 562505 ; 562553 ; 562607 ; 564 57 ; 564152 ; 564153 ; 564155 ; 564161 ; 564163 ; 564164 ; 564169 ; 564180 ;
Abstract

The present invention provides a compound of the formula ##STR1## which inhibit squalene synthetase and cholesterol biosynthesis and are useful in the treatment of e.g., hyperlipidaemia, atherosclerosis, or fungal infections, processes for the preparation of the compounds of the invention, intermediates useful in these processes, and pharmaceutical compositions containing the compounds.


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