The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 14, 1998
Filed:
Feb. 03, 1997
Applicant:
Inventors:
Mark L Collins, Walnut Creek, CA (US);
Thomas Horn, Berkeley, CA (US);
Patrick J Sheridan, San Leandro, CA (US);
Brian D Warner, Martinez, CA (US);
Michael S Urdea, Alamo, CA (US);
Assignee:
Other;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07H / ; C07H / ; C12Q / ; C12P / ;
U.S. Cl.
CPC ...
536 245 ; 435-6 ; 435911 ; 435912 ; 435913 ; 536 221 ; 536231 ; 536243 ; 536 2431 ; 536 2432 ; 536 2433 ; 514 44 ;
Abstract
Methods are provided for substantially reducing background signals encountered in nucleic acid hybridization assays. The method is premised on the elimination or significant reduction of the phenomenon of nonspecific hybridization, so as to provide a detectable signal which is produced only in the presence the target polynucleotide of interest. In addition, a novel method for the chemical synthesis of isoguanosine or 2'-deoxy-isoguanosine is provided. The invention also has applications in antisense and aptamer therapeutics and drug discovery.