The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 14, 1998
Filed:
Oct. 31, 1996
Rajendra S Bhatnagar, Burlingame, CA (US);
Jing Jing Qian, San Bruno, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
Small peptide mimics of TGF-.beta., having the general sequence AA.sub.i -AA.sub.i+1 -AA.sub.i+2 followed by AA.sub.i+n shortly thereafter, have been prepared. In this sequence, AA.sub.i is alanine, asparagine, or leucine, AA.sub.i+1 is valine or isoleucine, AA.sub.i+2 is alanine, n is 3, 4, or 5 such that there are n-3 amino acid residues in between AA.sub.i+2 and AA.sub.i+n, and AA.sub.i+n is glutamic acid, aspartic acid, glutamine or asparagine. Because the essential requirement for TGF-.beta. activity is the peptide's ability to form a stable .beta.-bend structure under physiologic conditions, the inventive peptides are collectively referred to as .beta.-bend peptides. Compositions for applications such as tissue repair are also provided that comprise a biocompatible matrix having cytomodulin or a cytomodulin analog admixed with or carried by the matrix.