The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 14, 1998

Filed:

Mar. 26, 1997
Applicant:
Inventors:

Lawrence A Haff, Wilton, CT (US);

Enrico Picozza, Newtown, CT (US);

Will Bloch, San Mateo, CA (US);

Timothy M Woudenberg, Bethel, CT (US);

Assignee:

The Perkin-Elmer Corporation, Norwalk, CT (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N / ;
U.S. Cl.
CPC ...
422 681 ; 422 50 ; 422 62 ; 422 8205 ; 422 99 ; 422129 ; 422131 ; 422132 ; 422134 ; 422138 ; 422149 ; 422188 ; 422198 ; 422202 ; 422203 ; 435 911 ; 435 912 ; 435 915 ; 4352831 ; 4352861 ; 4352865 ; 4352891 ; 4352931 ; 4353031 ; 436501 ; 935 85 ; 935 88 ;
Abstract

Apparatus and method for performing a nucleic acid amplification reaction and preferably a polymerase chain reaction (PCR) in a reaction mixture in at least one capillary tube. Several different embodiments are disclosed. One embodiment cycles a sample through a capillary tube loop passing through two thermostatted fluid baths. Another embodiment has the capillary tube routed alternatingly between two heat exchangers to that the sample makes only one pass through the tube. Other embodiments maintain the heat exchangers stationary and translate the samples between them. Still further embodiments maintain the samples stationary and either automatically translate or rotate the heat exchangers past the samples contained within the capillary tubes to perform the thermal cycles necessary for the amplification reaction.


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