The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 07, 1998
Filed:
Jun. 07, 1995
Applicant:
Inventors:
Peter M Glazer, Guilford, CT (US);
L Michael Lin, Wilmington, DE (US);
Jay George, Gaithersburg, MD (US);
Assignees:
Yale University, New Haven, CT (US);
Codon Pharmaceuticals, Inc., Gaithersburg, MD (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N / ; C12Q / ; C12Q / ; C12P / ;
U.S. Cl.
CPC ...
4351723 ; 435-5 ; 435-6 ; 435 911 ; 435 912 ;
Abstract
Methods, compositions and kits for effecting homologous recombination are described. In one aspect, the method utilizes two introduced DNAs: (1) a mutagen-linked single-stranded oligonucleotide capable of specifically binding to double-stranded DNA to form a triple-stranded helix, and (2) a donor DNA fragment capable of undergoing homologous recombination with DNA targeted by the oligonucleotide.