The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 1998
Filed:
Aug. 05, 1994
Applicant:
Inventors:
Teruo Oku, Tsukuba, JP;
Chiyoshi Kasahara, Tsukuba, JP;
Takehiko Ohkawa, Tsukuba, JP;
Masashi Hashimoto, Tsukuba, JP;
Assignee:
Fujisawa Pharmaceutical Co., Ltd., Osaka, JP;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; C07D / ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
549332 ; 5142315 ; 514255 ; 514314 ; 514326 ; 514336 ; 514422 ; 514475 ; 544 59 ; 544162 ; 544170 ; 544370 ; 546153 ; 546220 ; 546269 ; 548517 ; 549332 ;
Abstract
Oxaspiro�2,5! octanes of the formula ##STR1## inhibit angiogenesis and are particularly suitable for the treatment of solid tumors. In preferred embodiments, R.sup.1 is a carbamoyl derivative, R.sup.2 is an alkoxy substituent and R.sup.3 is ##STR2## Pharmaceutical salts of these compounds, such as methyl, amonium and organic amine salts also exhibit desirable properties.