The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 1998
Filed:
Jun. 07, 1995
Dana L Johnson, Upper Black Eddy, PA (US);
Robert A Zivin, Lawrenceville, NJ (US);
Other;
Abstract
The present invention is directed to the dimerization of agonists and antagonists of cell surface receptors and particularly to peptide dimers which behave as cell surface receptor agonists in their dimeric form. Such receptors belong to the dimerization-mediated activation class often observed among receptors for growth and differentiation factors. The agonists of this class of receptors is understood to effect dimerization of the receptor and thus signal initiation. The present invention exemplifies dimers of erythropoietin (EPO) agonists and antagonists comprising a core amino acid sequence of X.sub.3 X.sub.4 X.sub.5 GPX.sub.6 TWX.sub.7 X.sub.8 (SEQ ID NO: 1) wherein each amino acid is indicated by standard one letter abbreviation; X.sub.3 can be C, A, .alpha.-amino-.gamma.-bromobutyric acid or Hoc; X.sub.4 can be R, H, L or W; X.sub.5 can be M, F, or I; X.sub.6 is independently selected from any one of the 20 genetically coded L-amino acids or the stereoisomeric D-amino acids; X.sub.7 can be D, E, I, L or V; and X.sub.8 can be C, A, .alpha.-amino-.gamma.-bromobutyric acid or Hoc, provided that either X.sub.3 or X.sub.8 is C or Hoc.